Alexis DeJoria worked her way up to the premier Funny Car class by starting in Super Gas before moving to a Super Comp dragster. From there, she progressed to Top Alcohol Funny Car where she raced and managed a team from 2009-2011. She experienced success at every level, winning a Super Comp national event as well as capturing a Top Alcohol Funny Car win at the 2011 NHRA Northwest Nationals in Seattle. 

Racing for Kalitta Motorsports, DeJoria made her professional Funny Car debut at the 2011 Dallas event. Her first career Funny Car win came in 2014 at the Arizona Nationals in Phoenix and was quickly followed that season by a win in Las Vegas and a victory at the historic U.S. Nationals in Indianapolis. She then went on to pick up victories at Las Vegas (2016) and Brainerd (2017) before she took a two-season hiatus from racing in 2018-2019. She returned to the series in 2020, partnering with Del Worsham to form DC Motorsports. She clinched national event win No. 6 in 2021 in Bristol at the facility where she powered to her first Funny Car final round in 2012.

In 2024, DeJoria announced she would be driving for Joe & PJ Maynard’s JCM Racing team where she competes as one half of the sport’s first all-female nitro team alongside European Top Fuel racer Ida Zetterström.